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(-)-Catechin gallate

CAS No. 130405-40-2

(-)-Catechin gallate ( (-)-Catechin 3-O-gallate | (-)-Catechin 3-gallate )

产品货号. M19422 CAS No. 130405-40-2

(-)-Catechin Gallate 可抑制 6PGD、IDH。 (-)-儿茶素没食子酸酯显示出对人 β 分泌酶的抑制作用。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥2041 有现货
10MG ¥3216 有现货
25MG ¥3993 有现货
50MG ¥5030 有现货
100MG ¥7549 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    (-)-Catechin gallate
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    (-)-Catechin Gallate 可抑制 6PGD、IDH。 (-)-儿茶素没食子酸酯显示出对人 β 分泌酶的抑制作用。
  • 产品描述
    (-)-Catechin Gallate displays inhibition of 6PGD IDH. (-)-Catechin Gallate displays inhibition of human Beta-secretase. (-)-Catechin Gallate possesses antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 and chloroquine-resistant Plasmodium falciparum K1.
  • 体外实验
    (-)-Catechin gallate (CG) directly interacts with DNA oligomers and inhibits the activity of COX-1 and COX-2 enzymes, the gene expression of matrix metalloproteinase-9 in macrophage-differentiated HL-60 myeloid leukemia cells, the adipocyte uptake of glucose by the transporter, GLUT4, and the activities of various proteasomes, i.e., the multicatalytic proteases responsible for the degradation of most cellular proteins. The relative cytotoxicities of a 3-day exposure to (-)-Catechin gallate are determined for cancerous CAL27 and HSG cells, immortalized epithelioid S-G cells, and normal HGF-1 gingival fibroblasts. The concentration at which toxicity (P≤0.01) initially occur is 25 μM (-)-Catechin gallate for S-G cells, 50 μM (-)-Catechin gallate for CAL27 cells, 62.5 μM (-)-Catechin gallate for HSG cells and 75 μM (-)-Catechin gallate for HGF-1 fibroblasts. The calculated neutral red (NR50) values for a 3-day exposure to (-)-Catechin gallate are 58 μM for S-G cells, 62 μM for CAL27 cells, 90 μM for HSG cells and 132 μM for HGF-1 fibroblasts.
  • 体内实验
    ——
  • 同义词
    (-)-Catechin 3-O-gallate | (-)-Catechin 3-gallate
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    130405-40-2
  • 分子量
    442.37
  • 分子式
    C22H18O10
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:10 mM
  • SMILES
    C1[C@H]([C@@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Babich H et al. In vitro cytotoxicity of (-)-catechin gallate a minor polyphenol in green tea. Toxicol Lett. 2007 Jul 10;171(3):171-80.
产品手册
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